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SUBSTITUTES APPENDIX A OF THE OMAC 1999
PROHIBITED CLASSES OF SUBSTANCES AND PROHIBITED METHODS
1st April 2000

(OLYMPIC MOVEMENT ANTI-DOPING CODE APPENDIX A)

1. PROHIBITED CLASSES OF SUBSTANCES

A. Stimulants
Prohibited substances in class (A) include the following examples:

amineptine, amiphenazole, amphetamines, bromantan, caffeine*,
carphedon, cocaine, ephedrines**, fencamfamin, mesocarb, pentetrazol,
pipradrol, salbutamol***, salmeterol***, terbutaline***,
... and related substances.

* For caffeine the definition of a positive is a concentration in urine greater than
12 micrograms per millilitre.
** For cathine, the definition of a positive is a concentration in urine greater than 5
micrograms per millilitre. For ephedrine and methylephedrine, the definition of a positive is a
concentration in urine greater than 10 micrograms per millilitre. For phenylpropanolamine and
pseudoephedrine, the definition of a positive is a concentration in urine greater than
25 micrograms per millilitre.
*** Permitted by inhaler only to prevent and/or treat asthma and exercise-induced asthma.
Written notification of asthma and/or exercise-induced asthma by a respiratory or team
physician is necessary to the relevant medical authority.

NOTE: All imidazole preparations are acceptable for topical use. Vasoconstrictors may
be administered with local anaesthetic agents. Topical preparations (e.g. nasal, ophthalmological,
rectal) of adrenaline and phenylephrine are permitted.


B. Narcotics
Prohibited substances in class (B) include the following examples:

buprenorphine, dextromoramide, diamorphine (heroin), methadone,
morphine, pentazocine, pethidine,
... and related substances.

NOTE: codeine, dextromethorphan, dextropropoxyphene, dihydrocodeine,
diphenoxylate, ethylmorphine, pholcodine, propoxyphene and tramadol are permitted.


C. Anabolic agents
Prohibited substances in class (C) include the following examples:
1. Anabolic androgenic steroids

a.
clostebol, fluoxymesterone, metandienone, metenolone, nandrolone,
19-norandrostenediol, 19-norandrostenedione, oxandrolone, stanozolol,
... and related substances.

b.
androstenediol, androstenedione, dehydroepiandrosterone (DHEA),
dihydrotestosterone, testosterone*,
... and related substances.

Evidence obtained from metabolic profiles and/or isotopic ratio measurements may be
used to draw definitive conclusions.

* The presence of a testosterone (T) to epitestostrone (E) ratio greater than six (6) to
one (1) in the urine of a competitor constitutes an offence unless there is evidence that this ratio
is due to a physiological or pathological condition, e.g. low epitestosterone excretion, androgen
producing tumour, enzyme deficiencies.

In the case of T/E greater than 6, it is mandatory that the relevant medical authority
conducts an investigation before the sample is declared positive. A full report will be written and
will include a review of previous tests, subsequent tests and any results of endocrine
investigations. In the event that previous tests are not available, the athlete should be tested
unannounced at least once per month for three months. The results of these investigations
should be included in the report. Failure to co-operate in the investigations will result in
declaring the sample positive.

2. Beta-2 agonists

bambuterol, clenbuterol, fenoterol, formoterol, reproterol, salbutamol*,
salmeterol*, terbutaline*,
... and related substances.

*Authorized by inhalation as described in Article (I.A.).

For salbutamol the definition of a positive under the anabolic agent category is a concentration
in urine greater than 1000 nanograms per millilitre.

D. Diuretics
Prohibited substances in class (D) include the following examples:

acetazolamide, bumetanide, chlortalidone, etacrynic acid, furosemide,
hydrochlorothiazide, mannitol*, mersalyl, spironolactone, triamterene,
... and related substances.

* Prohibited by intravenous injection.

E. Peptide hormones, mimetics and analogues
Prohibited substances in class (E) include the following examples and their analogues
and mimetics:

1. Chorionic Gonadotrophin (hCG) prohibited in males only;
2. Pituitary and synthetic gonadotrophins (LH) prohibited in males only;
3. Corticotrophins (ACTH, tetracosactide);
4. Growth hormone (hGH);
5. Insulin-like Growth Factor (IGF-1);
and all the respective releasing factors and their analogues;
6. Erythropoietin (EPO);
7. Insulin;
permitted only to treat athletes with certified insulin-dependent diabetes. Written
certification of insulin-dependent diabetes must be obtained from an endocrinologist or team
physician.

The presence of an abnormal concentration of an endogenous hormone in class (E)or
its diagnostic marker(s) in the urine of a competitor constitutes an offence unless it has been
proven to be due to a physiological or pathological condition.

2. PROHIBITED METHODS

The following procedures are prohibited:
1. Blood doping;
2. Administering artificial oxygen carriers or plasma expanders;
3. Pharmacological, chemical and physical manipulation.

3. CLASSES OF PROHIBITED SUBSTANCES IN CERTAIN
CIRCUMSTANCES

A. Alcohol
Where the rules of a responsible authority so provide, tests will be conducted for ethanol.

B. Cannabinoids
Where the rules of a responsible authority so provide, tests will be conducted for
cannabinoids (e.g. Marijuana, Hashish). At the Olympic Games, tests will be conducted for
cannabinoids. A concentration in urine of 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid
(carboxy-THC) greater than 15 nanograms per millilitre constitutes doping.

C. Local anaesthetics
Injectable local anaesthetics are permitted under the following conditions:

a. bupivacaine, lidocaine, mepivacaine, procaine, and related substances, can be used but
not cocaine. Vasoconstrictor agents may be used in conjunction with local
anaesthetics;
b. only local or intra-articular injections may be administered;
c. only when medically justified.
Where the rules of a responsible authority so provide, notification of administration may be
necessary.

D. Glucocorticosteroids
The systemic use of glucocorticosteroids is prohibited when administered orally, rectally,
or by intravenous or intramuscular injection.

E. Beta-blockers
Prohibited substances in class (E) include the following examples:

acebutolol, alprenolol, atenolol, labetalol, metoprolol, nadolol, oxprenolol,
propranolol, sotalol,
... and related substances.

Where the rules of a responsible authority so provide, tests will be conducted for beta-blockers.


SUMMARY OF URINARY CONCENTRATIONS
ABOVE WHICH IOC ACCREDITED LABORATORIES
MUST REPORT FINDINGS FOR SPECIFIC SUBSTANCES

caffeine	> 12 micrograms/millilitre
carboxy-THC	> 15 nanograms/millilitre
cathine	> 5 micrograms / milliltre
ephedrine	> 10 micrograms / milliltre
epitestosterone	> 200 nanograms / millilitre
methylephedrine	> 10 micrograms / millilitre
morphine	> 1 microgram / millilitre
19-norandrosterone	> 2 nanograms /millilitre in males
19-norandrosterone	> 5 nanograms/millilitre in females
phenylpropanolamine	> 25 micrograms / millilitre
pseudoephedrine	> 25 micrograms / millilitre
salbutamol
(as stimulant)	> 100 nanograms/millilitre
(as anabolic agent)	>1000 nanograms/millilitre
T/E ratio	> 6

4. OUT-OF-COMPETITION TESTING
Unless specifically requested by the responsible authority, out-of-competition testing is
directed solely at prohibited substances in class I.C. (Anabolic Agents), I.D. (Diuretics), I.E.
(Peptide Hormones, Mimetics and Analogues), and II (Prohibited Methods).

LIST OF EXAMPLES OF PROHIBITED SUBSTANCES
CAUTION: This is not an exhaustive list of prohibited substances. Many substances that do not
appear on this list are considered prohibited under the term "and related substances".
Athletes must ensure that any medicine, supplement, over-the-counter preparation or any other
substance they use does not contain any Prohibited Substance.

STIMULANTS:
amineptine, amfepramone, amiphenazole, amphetamine, bambuterol,
bromantan, caffeine, carphedon, cathine, cocaine, cropropamide,
crotethamide, ephedrine, etamivan, etilamphetamine, etilefrine,
fencamfamin, fenetylline, fenfluramine, formoterol, heptaminol, mefenorex,
mephentermine, mesocarb, methamphetamine, methoxyphenamine,
methylenedioxyamphetamine, methylephedrine, methylphenidate,
nikethamide, norfenfluramine, parahydroxyamphetamine, pemoline,
pentetrazol, phendimetrazine, phentermine, phenylephrine,
phenylpropanolamine, pholedrine, pipradrol, prolintane, propylhexedrine,
pseudoephedrine, reproterol, salbutamol, salmeterol, selegiline, strychnine,
terbutaline,

NARCOTICS:
buprenorphine, dextromoramide, diamorphine (heroin), hydrocodone,
methadone, morphine, pentazocine, pethidine,

ANABOLIC AGENTS :
androstenediol, androstenedione, bambuterol, boldenone, clenbuterol,
clostebol, danazol, dehydrochlormethyltestosterone,
dehydroepiandrosterone (DHEA), dihydrotestosterone, drostanolone,
fenoterol, fluoxymesterone, formebolone, formoterol, gestrinone,
mesterolone, metandienone, metenolone, methandriol, methyltestosterone,
mibolerone, nandrolone, 19-norandrostenediol, 19-norandrostenedione,
norethandrolone, oxandrolone, oxymesterone, oxymetholone, reproterol,
salbutamol, salmeterol, stanozolol, terbutaline, testosterone, trenbolone,

DIURETICS
acetazolamide, bendroflumethiazide, bumetanide, canrenone, chlortalidone,
ethacrynic acid, furosemide, hydrochlorothiazide, indapamide, mannitol
(by intravenous injection), mersalyl, spironolactone,
triamterene,

MASKING AGENTS
bromantan, diuretics (see above), epitestosterone, probenecid,
PEPTIDE HORMONES, MIMETICS AND ANALOGUES
ACTH, erythropoietin (EPO), hCG*, hGH, insulin, LH*, clomiphene*,
cyclofenil*, tamoxifen*,
* prohibited in males only

BETA BLOCKERS
acebutolol, alprenolol, atenolol, betaxolol, bisoprolol, bunolol, carteolol,
celiprolol, esmolol, labetalol, levobunolol, metipranolol, metoprolol, nadolol,
oxprenolol, pindolol, propranolol, sotalol, timolol.

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